They also noted that oxidative stress is one of the causes of chronic diseases and cancer. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. View the data on our Hypothyroidism Research page. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. Why not simply call it selenium deficiency? Acta Endocrinol 1988, 118:460464. 16.6k members in the AlternativeHealth community. I have so much to say about this I could write a book. CRF encompasses physical, emotional, and/or cognitive tiredness; is related to cancer or cancer treatments; and interferes with multiple dimensions of health-related quality of life (1-3).CRF is poorly understood, underrecognized, and undertreated. PLoSone 2011, 11:e27547. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. It was the therapist that I went to that referred me to a specialist who ran the correct tests. El almacenamiento o acceso tcnico es necesario para la finalidad legtima de almacenar preferencias no solicitadas por el abonado o usuario. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. Or that it was the many years of not being diagnosed with hypothyroidism, courtesy of daft blood test ranges, before finally tipping a TSH over 5 (or even 10) before treatment is commenced, by which time the damage is done. Risk of cancer in longterm levothyroxine users: Retrospective Keri Topouzian, D.O. Physician/Author - Facebook Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. Oops I have just bought my first jar of marmalade in over ten years! Endocrinol. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. I have been reading Izabella Wentz. UpToDate [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a 'TSH suppressor.' This is a news report of the research, so I can't learn the details of how the science was conducted. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. Patients with undertreated hypothyroidism at higher risk for longer Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. Hashimoto's disease progresses slowly over the years. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Allthewebsites Directory - A niche web directory offering website promotion and other webmaster resources. The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? Treating Elderly for Subclinical Hypothyroidism Can Boost Mortality Rates by D.ap Tue Feb 21, 2017 10:40 am, Powered by phpBB Forum Software phpBB Limited. Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. But what can be done for patients who are at low I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Whether it should be treated remains controversial. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. rocket fuel, pesticides, fluoride, which induce low thyroid function. Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. 2 Hypothyroidism is the most common type of thyroid disorder, and women's risk of hypothyroidism is five to eight times higher than that of . The study included more than 128,000 veterans aged 18 to 26 and found that, just 30.2% of females and 18.7% of males had received HPV vaccination. That's all. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism. For more, visitGreenMedInfo.comand Facebook.com/GreenMedInfo, or sign up forGreenMedInfos free e-Newsletter. Thank you for posting it, I agree we all need as much knowledge as we can get! Millions Treated For Hypothyroidism At Risk For Lung Cancer Targeted therapy for lung cancer: Side effects and more In comparison, 62.4% of female and 37% of male . [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. 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You are using an out of date browser. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. I am having a lot of trouble making any sense of this study. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. I don't think so. millions treated for hypothyroidism at risk for lung cancer There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. Millions of people who were not only wrongly diagnosed with 'cancers' and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. I've been on synthroid for 20+ years, scary. As you know, I appreciate people posting links that help us learn more about lung cancer, too. Thyroid dysfunction after immune checkpoint inhibitor treatment in a However, that information will still be included in details such as numbers of replies. I posted it to see what anyone had to add. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. LOL. Non-ASPS articles which could be relevant. Hashimoto's disease - Symptoms and causes - Mayo Clinic ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. Post In my view the paper isn't worth the pixels used to display it on a screen. ", Orsomeone posts something about, say a diet or supplement and them some people think they are something it "Cures lung cancer.". Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Once I got on the medication, the symptoms disappeared. [13] Hollowell JG, Staehling NW, Flanders WD. hyperthyroidism. A couple of caveats to note in this study: The authors found a statistical correlation between the increase in sales of the thyroid medicine Synthroid, and an increase in lung cancer in Italy. Clin Cancer Res 2011, 30:77. Heart problems. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. Join the Patient & Caregiver Network. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. Kelly Mellott on LinkedIn: Nodify Lung: Nodule Risk Assessment | Biodesix Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related diseases.. weight loss, anorexia). " Is Drug-Based Medicine a Form of Human Sacrifice? Is This the Real Reason You're Exhausted All the T Why An Alkaline Approach Can Successfully Treat Ca We're Losing the War on Cancer- Here's Why. Also, what is oxidised stress??? Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. JavaScript is disabled. arizona lockdown status today; tiktok unblocked from school; samantha and savannah concepcion and our In an attempt to show causation, the article notes "patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. I am just as much in the dark as some others on this site. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c Tokushima J Exp Med 1991, 38:2535. 2004 Jun;9(2):157-79. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. Note: Only a member of this blog may post a comment. 500+ pages of Natural Medicine Alternatives and Information. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)", International Journal of Human Nutrition and Functional Medicine, Osteoporosis Is Scurvy of the Bone, Not Calcium Deficiency, 6 Bodily Tissues That Can Be Regenerated Through Nutrition, 7 Simple Ways to Unclog Your Arteries Naturally, Herbal Cream Clears 87.7% of HPV Cases Naturally, How WHOLE Turmeric Heals the Damaged Brain. PLoSone 2011, 11:e27547. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. I wish I could say that my story was atypical. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. Is that what releases free radicals? [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. millions treated for hypothyroidism at risk for lung cancer Study: Millions Treated for - The Wellness Institute | Facebook I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. See more of Keri Topouzian, D.O. Nope. 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El almacenamiento o acceso tcnico que se utiliza exclusivamente con fines estadsticos annimos. Another recently approved drug is tepotinib (Tepmetko). Increased sleepiness. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. The American Lung Association connects patients, families, friends and caregivers for support and inspiration as they face lung cancer. Study: Millions Treated for Hypothyroidism At R - Thyroid UK The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. Cancer Risk After Radioactive Iodine Treatment for - PubMed Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. Asesora y Consultora Web3 para empresas. Just another excuse for keeping us on doses that are too low. Could be another marmalade how would we know? Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. I was sure that the paper had been discussed here shortly after publication in 2013, but cannot find the thread! [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. Forgot account? Also this study finds no link with breast cancer, when others have found a link. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. Monaldi Arch Chest Dis 2003, 59:140145. U.S. FDA Broadens Indication for Verzenio (abemaciclib) in HR+, HER2 Brit Med J 1978, 1:210212. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called subclinical hypothyroidism only detected via blood work. A place for patients and relatives. Symptoms. In my opinion, the science of the study doesn't support the conclusion. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. I think there is always a lot of confusion with cause and cure. Unfortunately, it's quite typical. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. Study: Millions Treated for Hypothyroidism at Risk of Lung Cancer Diagnosed 1/12 with lung cancer out of the blue. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. Kelly Mellott LinkedIn: Nodify Lung: Nodule Risk Assessment | Biodesix Patient characteristics. PMID: 11929079, [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. radioactive treatments. [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. Endocrinology 2008, 149:22412250. Increased sensitivity to cold. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Overtreatment, of course, is the hallmark danger of overdiagnosis.
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